Article
Distinct age-related pattern of mitochondrial somatic mutations across multiple sclerosis phenotypes.
Journal of neurology - 6 Jun 2026
Esposito Federica, Misra Kaalindi, Doyle Francesca, Clarelli Ferdinando, De Simone Antonio, Giordano Antonino, Visentin Giulia, Mascia Elisabetta, Rocca Maria Assunta, Filippi Massimo, Sorosina Melissa
Abstract excerpt
BACKGROUND: Mitochondrial dysfunction has been proposed as a contributor to neurodegeneration in multiple sclerosis (MS). While the accumulation of somatic mitochondrial DNA (mtDNA) mutations with age is well documented in other neurodegenerative conditions, its role in MS progression remains largely unexplored. The aim of this study was to investigate the association between age and somatic mtDNA mutation burden...
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