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Article

CD4+ T cell mitochondrial genotype in Multiple Sclerosis: a cross-sectional and longitudinal analysis.

Scientific reports - 29 Mar 2024

Cortes-Figueiredo Filipe, Asseyer Susanna, Chien Claudia, Zimmermann Hanna G, Ruprecht Klemens, Schmitz-Hübsch Tanja, Bellmann-Strobl Judith, Paul Friedemann, Morais Vanessa A

Abstract excerpt

Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS), with a largely unknown etiology, where mitochondrial dysfunction likely contributes to neuroaxonal loss and brain atrophy. Mirroring the CNS, peripheral immune cells from patients with MS, particularly CD4+ T cells, show inappropriate mitochondrial phenotypes and/or oxidative phosphorylation (OxPhos)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38553515
DOI: 10.1038/s41598-024-57592-z
PMCID: PMC10980703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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