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Article

The role of mitochondrial DNA variants and dysfunction in the pathogenesis and progression of multiple sclerosis.

Mitochondrion - 1 Mar 2025

Rahimi Darehbagh Ramyar, Khanmohammadi Shaghayegh, Rezaei Nima

Abstract excerpt

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). The etiology of MS remains elusive, with a complex interplay of genetic and environmental factors contributing to its pathogenesis. Recent studies showed mitochondrial DNA (mtDNA) as a potential player in the development and progression of MS. These studies encompassed mtDNA variants, copy number variations, and...

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Identifiers

PMID: 39732186
DOI: 10.1016/j.mito.2024.102002

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