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Article

Somatic mtDNA variation is an important component of Parkinson's disease

6 Nov 2015

Abstract excerpt

There is a growing body of evidence linking mitochondrial dysfunction, mediated either through inherited mitochondrial DNA (mtDNA) variation or mitochondrial proteomic deficit, to Parkinson's disease (PD). Yet, despite this, the role of somatic mtDNA point mutations and specifically point-mutational burden in PD is poorly understood. Here, we take advantage of recent technical and methodological advances to...

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PMID: 26639157
DOI: 10.1016/j.neurobiolaging.2015.10.036

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