Article
Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis.
Epigenomics - 1 Feb 2024
Stoccoro Andrea, Smith Adam R, Mosca Lorena, Marocchi Alessandro, Gerardi Francesca, Lunetta Christian, Lunnon Katie, Migliore Lucia, Coppedè Fabio
Abstract excerpt
Aim: To correlate mitochondrial D-loop region methylation levels and mtDNA copy number with disease duration in familial amyotrophic lateral sclerosis (ALS) patients. Patients & methods: The study population included 12 ALS patients with a mutation in SOD1 and 13 ALS patients with the C9orf72 hexanucleotide repeat expansion. Methylation levels of the D-loop region and mtDNA copy number were quantified using...
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