Article
Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes.
Nature communications - 14 Nov 2024
Silveira André Bortolini, Houy Alexandre, Ganier Olivier, Özemek Begüm, Vanhuele Sandra, Vincent-Salomon Anne, Cassoux Nathalie, Mariani Pascale, Pierron Gaelle, Leyvraz Serge, Rieke Damian, Picca Alberto, Bielle Franck, Yaspo Marie-Laure, Rodrigues Manuel, Stern Marc-Henri
Abstract excerpt
Transition of cytosine to thymine in CpG dinucleotides is the most frequent type of mutation in cancer. This increased mutability is commonly attributed to the spontaneous deamination of 5-methylcytosine (5mC), which is normally repaired by the base-excision repair (BER) pathway. However, the contribution of 5mC deamination in the increasing diversity of cancer mutational signatures remains poorly explored. We...
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