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Article

The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila.

Frontiers in endocrinology - 1 Jan 2026

Moulin Thiago C, Williams Michael J, Schiöth Helgi B

Abstract excerpt

Introduction: Obesity arises from the interplay between genetic predisposition, metabolic signaling, and neural circuits that regulate feeding and energy expenditure. Large-scale association studies repeatedly implicate regulators of Ras/Rap GTPase signaling in adiposity and metabolic risk, but the mechanisms linking these intracellular switch modules to neural control of energy balance remain unclear. Methods:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42244947
DOI: 10.3389/fendo.2026.1773383
PMCID: PMC13229727

Genes

RASA2
KRAS
LEP
RASA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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