Article

Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

2023-07-31

Abstract excerpt

Retinoic acid-induced 1 ( RAI1 ) haploinsufficiency causes Smith-Magenis syndrome (SMS), a genetic disorder with symptoms including hyperphagia, hyperlipidemia, severe obesity, and autism phenotypes. RAI1 is a transcriptional regulator with a pan-neural expression pattern and hundreds of downstream targets. The mechanisms linking neural Rai1 to body weight regulation remain unclear. Here we find that hypothalami...

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Literature Corpus work: 2c14e264-46a1-5fd6-a3c4-34f2926af1f3
DOI: 10.1101/2023.07.30.551185

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