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Article

A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila.

Cell metabolism - 10 Jan 2017

Beshel Jennifer, Dubnau Josh, Zhong Yi

Abstract excerpt

Leptin, a typically adipose-derived "satiety hormone," has a well-established role in weight regulation. Here we describe a functionally conserved model of genetically induced obesity in Drosophila by manipulating the fly leptin analog unpaired 1 (upd1). Unexpectedly, cell-type-specific knockdown reveals upd1 in the brain, not the adipose tissue, mediates obesity-related traits. Disrupting brain-derived upd1 in...

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Identifiers

PMID: 28076762
DOI: 10.1016/j.cmet.2016.12.013
PMCID: PMC5235317

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