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Article

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.

PLoS biology - 1 Nov 2021

Agrawal Neha, Lawler Katherine, Davidson Catherine M, Keogh Julia M, Legg Robert, Barroso Inês, Farooqi I Sadaf, Brand Andrea H

Abstract excerpt

The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establishing a functional relationship between these candidate genes and adiposity remains a significant challenge. We uncovered a large number of rare homozygous gene...

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Identifiers

PMID: 34748544
DOI: 10.1371/journal.pbio.3001255
PMCID: PMC8575313

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