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Article

A multicomponent screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes.

Molecular metabolism - 1 Jan 2021

Chalmers J, Tung Y C L, Liu C H, O'Kane C J, O'Rahilly S, Yeo G S H

Abstract excerpt

OBJECTIVE: More than 300 genetic variants have been robustly associated with measures of human adiposity. Highly penetrant mutations causing human obesity do so largely by disrupting satiety pathways in the brain and increasing food intake. Most of the common obesity-predisposing variants are in, or near, genes expressed highly in the brain, but little is known of their function. Exploring the biology of these...

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Source

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Identifiers

PMID: 33242659
DOI: 10.1016/j.molmet.2020.101127
PMCID: PMC7753202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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