Article

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling

2025-07-30

Abstract excerpt

Neurofibromatosis type 1 results from mutations in the Neurofibromin 1 gene and its encoded neurofibromin protein. This condition produces multiple symptoms, including tumors, behavioral alterations, and metabolic changes. Molecularly, neu-rofibromin mutations affect Ras activity, influencing multiple downstream signaling pathways, including MAPK (Raf/MEK/ERK) and PI3K/Akt/mTOR signaling. This pleiotropy raises t...

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Literature Corpus work: 1b05ec7f-8192-54bf-ac17-02756ff331ba
DOI: 10.1101/2025.07.25.666841

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