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Article

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling.

PLoS genetics - 1 Mar 2026

Botero Valentina, Barrios Jenifer, Knauss Anneke, Dahlen Greta, Rosendahl Ethan, Colodner Kenneth J, Tomchik Seth M

Abstract excerpt

Neurofibromatosis type 1 results from mutations in the NF1 gene and its encoded neurofibromin protein. This condition produces multiple symptoms, including tumors, behavioral alterations, and metabolic changes. Molecularly, neurofibromin mutations affect Ras activity, influencing multiple downstream signaling pathways, including MAPK (Raf/MEK/ERK) and PI3K/Akt/mTOR signaling. This pleiotropy raises the question...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41785270
DOI: 10.1371/journal.pgen.1012061
PMCID: PMC12974851

Genes

NF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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