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Article

Magnesium leachates suppress inflammatory phenotype of vascular smooth muscle cells by downregulating the NF-κB p50/KLF5 signaling.

Acta biomaterialia - 1 Jul 2026

Wu Meichun, Xun Min, Li Jincheng, Lin Yukang, Zhou Tianle, Chen Yuping

Abstract excerpt

BACKGROUND: Atherosclerosis is a chronic inflammatory disease in which vascular smooth muscle cells (VSMCs) undergo phenotypic switching. Inflammatory, macrophage-like VSMCs contribute to neointimal hyperplasia and plaque instability. Biodegradable magnesium (Mg)-based stents have favorable mechanical and biological properties, but their in-situ degradation releases magnesium ions (Mg2+) that may modulate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42242406
DOI: 10.1016/j.actbio.2026.06.003

Genes

KLF5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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