Article

Reprogramming Human Inflammatory Macrophages in Symptomatic Carotid Stenosis: Potential Mechanisms for Stabilisation of Atherosclerotic Carotid Plaques

2024-06-13

Abstract excerpt

<h4>Background</h4> Inflammation is a precursor to atherosclerotic plaque destabilisation, leading to ischaemic events such as stroke. Macrophage phenotypes can be altered by the microenvironment, and certain anti-inflammatory agents may, therefore, stabilise plaques and reduce the risk of recurrent ischaemic events. <h4>Methods</h4> Thirteen carotid plaques were obtained from stroke/ Transient Ischaemic Attack...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d26626eb-2532-5285-b41c-a67f2a968b35
DOI: 10.1101/2024.06.11.598440

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reprogramming Human Inflammatory Macrophages in Symptomatic Carotid Stenosis: Potential Mechanisms for Stabilisation of Atherosclerotic Carotid PlaquesDOI 10.1101/2024.06.11.598440Read

Macrophage Plasticity and Atherosclerosis TherapySemantic proximity Read

Regulation of Macrophage Activation and Differentiation in AtherosclerosisSemantic proximity Read

M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human AtherosclerosisSemantic proximity Read

Understanding the role of alternative macrophage phenotypes in human atherosclerosis.Semantic proximity Read

Pathophysiological relevance of macrophage subsets in atherogenesis.Semantic proximity Read

Deciphering Macrophage Phenotypes upon Lipid Uptake and AtherosclerosisSemantic proximity Read

CXCL16 promotes macrophage-driven inflammation and vascular smooth muscle cell phenotypic switching during carotid plaque destabilization.Semantic proximity Read

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.Semantic proximity Read

Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment.Semantic proximity Read

NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis.Semantic proximity Read

Redefining Macrophage Heterogeneity in Atherosclerosis: A Focus on Possible Therapeutic ImplicationsSemantic proximity Read

Macrophage Diversity and Polarization in AtherosclerosisSemantic proximity Read