Article

CXCL4-induced PBMCs Modulate Vascular Extracellular Matrix through Wnt5a-CaMKII-dependent Release of Calcific Extracellular Vesicles and Matrix Metalloproteinase-7

2023-05-23

Abstract excerpt

<h4>Background</h4> Macrophage heterogeneity plays an increasing role in the study of vascular inflammatory responses. The CXCL4-induced monocyte/macrophage phenotype has previously been implicated with atherosclerotic plaque destabilization, a key process preceding plaque rupture. Monocyte-derived macrophages were found to exhibit a unique transcriptome in the presence of CXCL4 characterized by upregulation of S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4eea5759-a996-54d4-abbb-47c0711b47fb
DOI: 10.1101/2023.05.15.540832

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CXCL4-induced PBMCs Modulate Vascular Extracellular Matrix through Wnt5a-CaMKII-dependent Release of Calcific Extracellular Vesicles and Matrix Metalloproteinase-7DOI 10.1101/2023.05.15.540832Read

CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Matrix Metalloproteinase-7 and Calcifying Extracellular Vesicle Release.Semantic proximity Read

Multiomics unveils extracellular vesicle-driven mechanisms of endothelial communication in human carotid atherosclerosisSemantic proximity Read

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read

Patient-Derived Circulating Monocytes Promote Calcific Aortic Valve Disease ProgressionSemantic proximity Read

CXCL16 promotes macrophage-driven inflammation and vascular smooth muscle cell phenotypic switching during carotid plaque destabilization.Semantic proximity Read

Conserved and Divergent Modulation of Calcification in Atherosclerosis and Aortic Valve Disease by Tissue Extracellular VesiclesSemantic proximity Read

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteriesSemantic proximity Read

Identification of potential biomarkers in cardiovascular calcification based on bioinformatics combined with single-cell RNA-seq and multiple machine learning analysisSemantic proximity Read

Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve diseaseSemantic proximity Read

The Dual Role of Extracellular Vesicles in Atherosclerosis: From Pathogenic Mediators to Translational Tools in Diagnosis and Targeted TherapySemantic proximity Read

Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic PlaquesSemantic proximity Read

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Semantic proximity Read