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Article

Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis.

Journal of vascular research - 1 Jan 2010

Pallero Manuel A, Talbert Roden Melissa, Chen Yiu-Fai, Anderson Peter G, Lemons Jack, Brott Brigitta C, Murphy-Ullrich Joanne E

Abstract excerpt

BACKGROUND/AIMS: Despite advances in stent design, in-stent restenosis (ISR) remains a significant clinical problem. All implant metals exhibit corrosion, which results in release of metal ions. Stainless steel (SS), a metal alloy widely used in stents, releases ions to the vessel wall and induces reactive oxygen species, inflammation and fibroproliferative responses. The molecular mechanisms are unknown....

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Source

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Identifiers

PMID: 20016205
DOI: 10.1159/000265565
PMCID: PMC2895758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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