Article

Polyethylene and Polyvinyl Chloride Nanoplastics Accelerate Atherosclerosis Through Distinct Smooth Muscle Cell Phenotypic Transitions

2026-02-14

Abstract excerpt

Micro- and nanoplastics (MNPs) are increasingly detected in human tissues, yet their causal contribution to cardiovascular disease remains poorly understood. Here we show that oral exposure to polyethylene (PE) and polyvinyl chloride (PVC) -- the most abundant polymers found in human atheromas -- accelerates atherosclerosis in ApoE-/- mice through distinct, polymer-specific molecular mechanisms. While both polymer...

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Literature Corpus work: 57842bdf-7d5e-5065-baaa-2a682ff48d61
DOI: 10.64898/2026.02.10.26345390

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