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Article

Magnesium incorporation in fibrinogen scaffolds promotes macrophage polarization towards M2 phenotype.

Acta biomaterialia - 1 Jan 2023

Bessa-Gonçalves M, Ribeiro-Machado C, Costa M, Ribeiro C C, Barbosa J N, Barbosa M A, Santos S G

Abstract excerpt

The host inflammatory response to biomaterials conditions their capacity to promote tissue repair, and macrophage polarization shift from M1 to M2 is determinant in this process. Previous work showed that extracts of a combination between fibrinogen and metallic magnesium materials acted synergistically to reduce macrophage inflammatory phenotype. The hypothesis underlying the current work was that the ability of...

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PMID: 36328124
DOI: 10.1016/j.actbio.2022.10.046

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