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Article

Comprehensive analysis of TNF-alpha gene polymorphism: A computational approach.

Human immunology - 1 Aug 2026

Gaba Kajal, Pushkarna Samridhi, Malhotra Parveen, Kumar Anil, Suneja Pooja, Dang Amita Suneja

Abstract excerpt

BACKGROUND: TNF-alpha, a potent cytokine produced by immune cells, regulates inflammation and immune responses. Understanding the genetic variations in TNF-alpha gene nsSNP and regulatory SNPs within the UTRs can help in elucidating the mechanisms of disease pathogenesis. OBJECTIVE: Present study involved a comprehensive analysis of the TNF-alpha gene to identify deleterious SNPs within its UTR and coding region....

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PMID: 42242098
DOI: 10.1016/j.humimm.2026.111766

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TNF

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