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In silico analysis of missense SNPs in TNFR1a and their possible therapeutic or pathogenic role in immune diseases.

Human immunology - 1 Nov 2023

Arshad Maria, Noor Nabeel, Iqbal Zunair, Jaleel Hadiqa

Abstract excerpt

Tumor necrosis factor alpha (TNFa) is an inflammatory cytokine that is involved in the pathogenesis of various inflammatory disorders including rheumatoid arthritis. TNF-alpha receptor I (TNFR1a) is one of the receptors TNFa binds with for its activation. Any variation in this receptor might affect the role of TNFa in successive events. Amino acid residue substitutions might happen in TNFR1a through...

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PMID: 37748952
DOI: 10.1016/j.humimm.2023.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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