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Functional and Structural Impact of Deleterious Missense Single Nucleotide Polymorphisms in the NR3C1, CYP3A5, and TNF-α Genes: An In Silico Analysis.

Biomolecules - 16 Sept 2022

Ramayanam Navakanth Raju, Manickam Ranjani, Mahalingam Vijayakumar Thangavel, Goh Khang Wen, Ardianto Chrismawan, Ganesan Poovi, Ming Long Chiau, Ganesan Rajanandh Muhasaparur

Abstract excerpt

Human diseases are generally influenced by SNPs (single nucleotide polymorphisms). The mutations in amino acid residues generated by deleterious SNPs contribute to the structural and functional diversity of the encoded protein. Tumor necrosis factor-α (TNF-α), Glucocorticoid receptor gene (NR3C1), and Cytochrome P450 3A5 (CYP3A5) play a key role in glucocorticoid resistance susceptibility in humans. Possible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36139147
DOI: 10.3390/biom12091307
PMCID: PMC9496109

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