Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mislocalization of protein kinase A drives pathology in Cushing’s syndrome

1 Jul 2022

Abstract excerpt

Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R and W196R variants. Proximity proteomic techniques demonstrate that both Cushing's mutants are excluded from A kinase-anchoring protein (AKAP)-signaling islands, whereas live-cell photoactivation microscopy reveals that these kinase mutants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Mechanics and Interactions
Share to Hippo pathway signaling and YAP/TAZ
Share to Pituitary Gland Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35830806
DOI: 10.1016/j.celrep.2022.111073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mislocalization of protein kinase A drives pathology in Cushing’s syndromePMID 35830806Read ↗

Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing’s syndromeSemantic proximity Read ↗

Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPsSemantic proximity Read ↗

Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI.Semantic proximity Read ↗

Local protein kinase A signaling pathologies in the endocrine system.Semantic proximity Read ↗

Structural insights into mis-regulation of protein kinase A in human tumors.Semantic proximity Read ↗

Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing SyndromeSemantic proximity Read ↗

Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome.Semantic proximity Read ↗

PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.Semantic proximity Read ↗

Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling.Semantic proximity Read ↗

Activating PRKACB somatic mutation in cortisol-producing adenomas.Semantic proximity Read ↗

Phosphoproteomic dysregulation drives tumor proliferation in Cushing’s diseaseSemantic proximity Read ↗

Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.