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Article

Protein Kinase A Alterations in Adrenocortical Tumors

8 Aug 2014

Abstract excerpt

Stimulation of the cAMP pathway by adrenocorticotropin (ACTH) is essential for adrenal cortex maintenance, glucocorticoid and adrenal androgens synthesis, and secretion. Various molecular and cellular alterations of the cAMP pathway have been observed in endocrine tumors. Protein kinase A (PKA) is a central key component of the cAMP pathway. Molecular alterations of PKA subunits have been observed in...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 25105543
DOI: 10.1055/s-0034-1385908

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