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Article

Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI.

The Biochemical journal - 28 Jun 2023

Omar Mitchell H, Kihiu Maryanne, Byrne Dominic P, Lee Kyung-Soon, Lakey Tyler M, Butcher Erik, Eyers Patrick A, Scott John D

Abstract excerpt

Cushing's syndrome is an endocrine disorder caused by excess production of the stress hormone cortisol. Precision medicine strategies have identified single allele mutations within the PRKACA gene that drive adrenal Cushing's syndrome. These mutations promote perturbations in the catalytic core of protein kinase A (PKAc) that impair autoinhibition by regulatory subunits and compartmentalization via recruitment...

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Identifiers

PMID: 37306403
DOI: 10.1042/BCJ20230183
PMCID: PMC11136536

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