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PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors

20 May 2015

Abstract excerpt

Cyclic-AMP (cAMP)-dependent protein kinase (PKA) is the main effector of cAMP signaling in all tissues. Inactivating mutations of the PRKAR1A gene, coding for the type 1A regulatory subunit of PKA, are responsible for Carney complex and primary pigmented nodular adrenocortical disease (PPNAD). PRKAR1A inactivation and PKA dysregulation have been implicated in various types of adrenocortical pathologies associated...

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PMID: 26042218
DOI: 10.3389/fcell.2015.00026

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