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Article

Efficient biomanufacturing of vitamin E succinate in non-aqueous media via synergistic computational evolution and immobilization of lipase.

Bioresource technology - 1 Oct 2026

Zhang Zihan, Zhang Yu, Liu Qingqing, Song Wanqing, Hu Yi, Nian Binbin

Abstract excerpt

Biocatalysts exhibit broad application prospects in industrial production. However, the inherent instability of natural enzymes in non-aqueous media severely limits their practical utilization. Using Candida rugosa lipase as a model, a synergistic evolution strategy integrating ancestral sequence reconstruction, free energy optimization and surface hydration shell modulation was developed in this study. The...

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PMID: 42235695
DOI: 10.1016/j.biortech.2026.135069

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