Role of conformational dynamics in the evolution of novel enzyme function.

Abstract excerpt

The free energy landscape concept that describes enzymes as an ensemble of differently populated conformational sub-states in dynamic equilibrium is key for evaluating enzyme activity, enantioselectivity, and specificity. Mutations introduced in the enzyme sequence can alter the populations of the pre-existing conformational states, thus strongly modifying the enzyme ability to accommodate alternative substrates,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biocatalysis
• Share to Catalytic Domain