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Article

[Improving the thermal stability of Bacillus subtilis lipase based on multiple computational design strategies].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 25 Aug 2020

Xiang Yu, Zhang Meng, Xu Fei

Abstract excerpt

Improving the thermal stability of enzymes is a hot and difficult point in the field of biocatalysis. Compared with the traditional directed evolution, computational assisted rational design is more efficient, and is widely used in enzyme engineering. Using Bacillus subtilis LipA as the model protein, the structure cavity of the enzyme was analyzed by Rosetta-VIP design, the mutation which was beneficial to the...

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PMID: 32924354
DOI: 10.13345/j.cjb.190535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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