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Design Glutamate Dehydrogenase for Nonaqueous System by Motifs Reassembly and Interaction Network Analysis.

Journal of agricultural and food chemistry - 11 Sept 2024

Zhang Qian, Chen Yuxin, Duan Lingxuan, Dong Lingling, Wang Shizhen

Abstract excerpt

Glutamate dehydrogenases (GDH) serve as the key regulated enzyme that links protein and carbohydrate metabolism. Combined with motif reassembly and mutation, novel GDHs were designed. Motif reassembly of thermophilic GDH and malate dehydrogenase aims to overcome stability and activity tradeoff in nonaqueous systems. Structural compatibility and dynamic cooperation of the designed AaDHs were studied by molecular...

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PMID: 39222309
DOI: 10.1021/acs.jafc.4c02995

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