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Lethal effects of a hyperactive dGTP triphosphohydrolase in E. coli.

Genetics - 5 Aug 2026

Bhawsinghka Niketa, Glenn Katie F, Klemm Bradley P, Singh Deepa, Day Ryan C, Cochran Robert Z, Schaaper Roel M

Abstract excerpt

Escherichia coli possesses a unique class of dNTPases, known as deoxyguanosine triphosphohydrolase (dGTPase), which hydrolyses the DNA precursor dGTP into deoxyguanosine and tripolyphosphate. The enzyme has a fidelity role, as deletion of the encoding dgt gene results in a mutator effect. The Dgt enzyme is a protein hexamer subject to allosteric regulation by dGTP substrate itself and by ssDNA. In the present...

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PMID: 42234826
DOI: 10.1093/genetics/iyag139
PMCID: PMC13394429

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