Article
A phage mechanism for selective nicking of dUMP-containing DNA.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2021
Mahata Tridib, Molshanski-Mor Shahar, Goren Moran G, Jana Biswanath, Kohen-Manor Miriam, Yosef Ido, Avram Oren, Pupko Tal, Salomon Dor, Qimron Udi
Abstract excerpt
Bacteriophages (phages) have evolved efficient means to take over the machinery of the bacterial host. The molecular tools at their disposal may be applied to manipulate bacteria and to divert molecular pathways at will. Here, we describe a bacterial growth inhibitor, gene product T5.015, encoded by the T5 phage. High-throughput sequencing of genomic DNA of bacterial mutants, resistant to this inhibitor, revealed...
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