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Article

Structure of Escherichia coli dGTP triphosphohydrolase: a hexameric enzyme with DNA effector molecules.

The Journal of biological chemistry - 17 Apr 2015

Singh Deepa, Gawel Damian, Itsko Mark, Hochkoeppler Alejandro, Krahn Juno M, London Robert E, Schaaper Roel M

Abstract excerpt

The Escherichia coli dgt gene encodes a dGTP triphosphohydrolase whose detailed role still remains to be determined. Deletion of dgt creates a mutator phenotype, indicating that the dGTPase has a fidelity role, possibly by affecting the cellular dNTP pool. In the present study, we have investigated the structure of the Dgt protein at 3.1-Å resolution. One of the obtained structures revealed a protein hexamer that...

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Identifiers

PMID: 25694425
DOI: 10.1074/jbc.M115.636936
PMCID: PMC4400351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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