Tumour-Derived Extracellular Vesicles Reprogramme Tumour-Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma.

doi:10.1002/jev2.70317

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Article

Tumour-Derived Extracellular Vesicles Reprogramme Tumour-Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma.

Journal of extracellular vesicles - 1 Jun 2026

Pan Xiu-Wu, Li Mu-Chen, Yang Tian-Yue, Liu Yi-Fan, Zhou Jia-Lin, Tang Yi-Fan, Zheng Hong-Feng, Liu Jian-Gui, Liu Zi-Chang, Ma Wen-Jie, Li Wen-Yan, Gong Zi-Xuan, Zhang Shun, Zhang Hang-Biao, Lu Bing-Nan, Yao Yun-Tao, Lyu Dong-Hao, Zhu Guan-Yu, Zong Yuan-Bo, Yao Han-Lin, Zhang Ai-Ping, Zeng Jin, Xiong Si-Tu, Dong Ke-Qin, Zhou Wang, Fu Bin, Cui Xin-Gang

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC)-derived extracellular vesicles (EVs) play a pivotal role in myeloid cell differentiation toward immunosuppressive phenotypes, yet the underlying mechanisms remain poorly understood. Through integrated single-nucleus RNA sequencing, EV proteomics, and phenotype validation, we identified NOD1, a pattern recognition receptor (PRR), as a critical mediator of EV-driven...

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Identifiers

PMID: 42226559
DOI: 10.1002/jev2.70317
PMCID: PMC13239502

Genes

NOD1
SCRIB
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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