Article

Extracellular vesicle-mediated suppression of macrophage STING signaling promotes immune dysfunction in dedifferentiated liposarcoma

2026-08-10

Abstract excerpt

<h4>Background</h4> Dedifferentiated liposarcoma (DDLPS) is characterized by abundant immune cell infiltration yet derives limited benefit from immune checkpoint blockade and stimulator of interferon genes (STING) agonist-based strategies, suggesting tumor-mediated suppression of antitumor immunity. Tumor-associated macrophages are the most abundant immune populations in DDLPS, but the factors regulating their fu...

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Literature Corpus work: c6169b8e-fd28-5f04-a9e2-881222b76d08
DOI: 10.64898/2026.08.07.743624

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