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MDK promotes M2 macrophage polarization to remodel the tumour microenvironment in clear cell renal cell carcinoma

6 Aug 2024

Abstract excerpt

The efficacy of immunotherapy for clear cell renal cell carcinoma (ccRCC), especially advanced ccRCC, is limited, presenting a clinical challenge. This limitation is closely tied to the immune regulation network. Understanding the heterogeneity of the tumour microenvironment (TME) is crucial for developing advanced ccRCC therapies. Using publicly available ccRCC data (scRNA-seq, bulk RNA-seq, and somatic mutation...

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PMID: 39107475
DOI: 10.1038/s41598-024-69183-z

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