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Long-read RNA sequencing redefines the clear cell renal cell carcinoma transcriptome and reveals novel genes and transcripts associated with disease recurrence and immune evasion

2023-09-08

Abstract excerpt

<h4>Background</h4> Long-read direct RNA sequencing (DRS) and PCR cDNA sequencing (PCS) of tumour samples could lead to discovery of novel transcript isoforms, novel genes, and transcriptomic co-dependencies missed by conventional short-read sequencing. However, only a handful of reports using DRS or PCS in cancer exist with no direct comparison between the two methods. Clear cell renal cell carcinoma (ccRCC) is t...

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Literature Corpus work
fc14dd29-27a9-5825-886b-ae16ef983494
DOI
10.1101/2023.09.08.23295204
Open publication

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Long-read RNA sequencing redefines the clear cell renal cell carcinoma transcriptome and reveals novel genes and transcripts associated with disease recurrence and immune evasionDOI 10.1101/2023.09.08.23295204
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