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Proteomic characterization of sporadic clear cell renal cell carcinoma reveals a matrix-dense pseudocapsule and heterogeneous tumor subtypes

2025-10-23

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) frequently develops a fibrotic pseudocapsule (PC) at the tumor boundary, yet its implications in the disease remain incompletely defined. We performed DIA-based proteomics on formalin-fixed, paraffin-embedded (FFPE) specimens of sporadic ccRCC from 153 patients, comprising 142 tumor, 123 pseudocapsule (PC), and 121 non-malignant adjacent tissue (NAT) samples. The PC displaye...

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Literature Corpus work
efb0a81c-a187-56e5-8a44-d959b36279fa
DOI
10.1101/2025.10.23.683844
Open publication

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Proteomic characterization of sporadic clear cell renal cell carcinoma reveals a matrix-dense pseudocapsule and heterogeneous tumor subtypesDOI 10.1101/2025.10.23.683844
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