Article
A Conjugate of Aminoadamantane and Tetrahydro-γ-Carboline Inhibits Accumulation of Mutant α-Synuclein A53T in the Cellular Model of Proteinopathy.
Biochemistry. Biokhimiia - 1 May 2026
Burak Marina V, Pukaeva Nadezhda E, Kryshkova Victoria S, Kukharskaya Olga A, Nazdracheva Maya R, Pukhov Sergey A, Rachenkov Kirill A, Stavrovskaya Alla V, Fisenko Vladimir P, Kukharsky Michail S, Bachurin Sergei O
Abstract excerpt
Pathological aggregation of α-synuclein is a key event in the development of synucleinopathies, such as Parkinson's disease and Lewy body dementia. Currently, no effective disease-modifying therapy is available, necessitating the search for new therapeutic agents. One promising strategy involves the use of low-molecular-weight compounds capable of inhibiting the formation of toxic protein aggregates. This study...
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