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Article

Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.

Journal of neurochemistry - 1 Jul 2010

Jiang Mali, Porat-Shliom Yair, Pei Zhong, Cheng Yong, Xiang Lan, Sommers Katherine, Li Qing, Gillardon Frank, Hengerer Bastian, Berlinicke Cynthia, Smith Wanli W, Zack Donald J, Poirier Michelle A, Ross Christopher A, Duan Wenzhen

Abstract excerpt

The E46K is a point mutation in alpha-synuclein (alpha-syn) that causes familial Parkinsonism with Lewy body dementia. We have now generated a cell model of Parkinsonism/Parkinson's disease (PD) and demonstrated cell toxicity after expression of E46K in the differentiated PC12 cells. E46K alpha-syn inhibited proteasome activity and induced mitochondrial depolarization in the cell model. Baicalein has been...

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Identifiers

PMID: 20412383
DOI: 10.1111/j.1471-4159.2010.06752.x
PMCID: PMC2910156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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