Article

Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formation

2020-11-17

Abstract excerpt

Alzheimer’s disease is imposing a growing social and economic burden worldwide and effective therapies are required. Strategies aimed at the removal of fibrillar plaques formed by the amyloid-β peptide have not proved therapeutic and the focus has shifted to approaches that target the cytotoxic oligomeric amyloid-β species that are populated before fibrils are deposited. We have designed and synthesized perphenazi...

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Literature Corpus work: cc36359e-2f2a-558b-9384-1675b05e604e
DOI: 10.1101/2020.11.16.384248

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Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formationDOI 10.1101/2020.11.16.384248Read

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