Article
The Familial α-Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers.
Biochemistry - 21 Aug 2018
Mohite Ganesh M, Navalkar Ambuja, Kumar Rakesh, Mehra Surabhi, Das Subhadeep, Gadhe Laxmikant G, Ghosh Dhiman, Alias Basil, Chandrawanshi Vikas, Ramakrishnan Aishwarya, Mehra Sarika, Maji Samir K
Abstract excerpt
Amyloid formation of α-synuclein (α-Syn) and its familial mutations are directly linked with Parkinson's disease (PD) pathogenesis. Recently, a new familial α-Syn mutation (A53E) was discovered, associated with an early onset aggressive form of PD, which delays α-Syn aggregation. When we overexpressed wild-type (WT) and A53E proteins in cells, showed neither toxicity nor aggregate formation, suggesting merely...
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