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Article

A routinely used protein staining dye acts as an inhibitor of wild type and mutant alpha-synuclein aggregation and modulator of neurotoxicity.

European journal of medicinal chemistry - 1 Jan 2018

Ahsan Nuzhat, Siddique Ibrar Ahmed, Gupta Sarika, Surolia Avadhesha

Abstract excerpt

Inhibition of amyloid formation along with modulation of toxicity employing small molecules is emerging as a potential therapeutic approach for protein misfolding disorders which includes Parkinson's disease, Alzheimer's disease and Multiple System Atrophy etc. Countless current interventional strategies for treating α-synucleinopathies consider using peptidic and non-peptidic inhibitors for arresting...

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Identifiers

PMID: 29150334
DOI: 10.1016/j.ejmech.2017.10.002

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