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Article

OmpK36 deficiency and inducible AmpC β-lactamase synergistically drive imipenem resistance in Klebsiella aerogenes.

Microbiology spectrum - 7 Jul 2026

Shang Shumi, Chen Liyang, Li Xiaosi, Xu Siqi, Shen Heping, Hu Fuping, Tang Wenting, Wu Xiaoyan

Abstract excerpt

This study systematically elucidates how ST88-KL186 Klebsiella aerogenes evolved carbapenem resistance through a dual synergistic mechanism involving porin deficiency and inducible AmpC β-lactamase, providing a mechanistic explanation for carbapenem resistance independent of carbapenemase production. From seven homologous strains (single-nucleotide polymorphism [SNP] difference 3-30) consecutively isolated from a...

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Identifiers

PMID: 42212662
DOI: 10.1128/spectrum.04108-25
PMCID: PMC13340039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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