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Article

Recurrent emergence of Klebsiella pneumoniae carbapenem resistance mediated by an inhibitory ompK36 mRNA secondary structure.

Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2022

Wong Joshua L C, David Sophia, Sanchez-Garrido Julia, Woo Jia Z, Low Wen Wen, Morecchiato Fabio, Giani Tommaso, Rossolini Gian Maria, Beis Konstantinos, Brett Stephen J, Clements Abigail, Aanensen David M, Rouskin Silvi, Frankel Gad

Abstract excerpt

Outer membrane porins in Gram-negative bacteria facilitate antibiotic influx. In Klebsiella pneumoniae, modifications in the porin OmpK36 are implicated in increasing resistance to carbapenems. An analysis of large K. pneumoniae genome collections, encompassing major healthcare-associated clones, revealed the recurrent emergence of a synonymous cytosine-to-thymine transition at position 25 (25c > t) in ompK36. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36095213
DOI: 10.1073/pnas.2203593119
PMCID: PMC9499542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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