Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy.

doi:10.1128/spectrum.00356-26

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Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy.

Microbiology spectrum - 1 Sept 2026

Li Fu-Hao, Zheng Mei, Zhong Gong-Mei, He Xue-Mei, Hu Meng-Zhen, Kuang Xu, Wu Jing-Jing, Li Chang-Min, Wang Jia-Ning, Zhou Xiao-Yu, Yu Yang

Abstract excerpt

The ceftazidime/avibactam (CAZ-AVI, CZA) combination is a potent agent against KPC-producing Klebsiella pneumoniae (KPC-Kp) infections, but resistance readily emerges via KPC mutations that restore carbapenem susceptibility. Previous studies have shown that the CZA-meropenem (MEM) combination exhibits favorable therapeutic efficacy by exploiting this collateral sensitivity. Here, we investigated in vitro how this...

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Topics

Ceftazidime
Klebsiella pneumoniae
Azabicyclo Compounds
Drug Combinations
beta-Lactamases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Anti-Bacterial Agents

Klebsiella Infections

Mutation

Microbial Sensitivity Tests

Humans

Bacterial Proteins

Third Generation Cephalosporins

Drug Resistance, Multiple, Bacterial

Molecular Docking Simulation

Source

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Identifiers

PMID: 42545018
DOI: 10.1128/spectrum.00356-26
PMCID: PMC13532191

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