Article

Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of <i>Klebsiella pneumoniae</i>

2022-02-07

Abstract excerpt

Mutations in outer membrane porins act in synergy with carbapenemase enzymes to increase carbapenem resistance in the important nosocomial pathogen, Klebsiella pneumoniae (KP). A key example is a di-amino acid insertion, Glycine-Aspartate (GD), in the extracellular loop 3 (L3) region of OmpK36 which constricts the pore and restricts entry of carbapenems into the bacterial cell. Here we combined genomic and experi...

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Literature Corpus work: 125a07dc-3763-55fb-890a-a6d7e82fa4b9
DOI: 10.1101/2022.02.07.479342

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