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Article

Phage-mediated virulence loss and antimicrobial susceptibility in carbapenem-resistant Klebsiella pneumoniae.

mBio - 5 Feb 2025

Yu Yanshuang, Wang Mengzhu, Ju Liuying, Li Minchun, Zhao Mengshi, Deng Hui, Rensing Christopher, Yang Qiu E, Zhou Shungui

Abstract excerpt

Bacteriophages, known for their ability to kill bacteria, are hampered in their effectiveness because bacteria are able to rapidly develop resistance, thereby posing a significant challenge for the efficacy of phage therapy. The impact of evolutionary trajectories on the long-term success of phage therapy remains largely unclear. Herein, we conducted evolutionary experiments, genomic analysis, and CRISPR-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39714187
DOI: 10.1128/mbio.02957-24
PMCID: PMC11796411

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