Article
Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin.
Antimicrobial agents and chemotherapy - 1 Nov 2013
Clancy Cornelius J, Chen Liang, Hong Jae H, Cheng Shaoji, Hao Binghua, Shields Ryan K, Farrell Annie N, Doi Yohei, Zhao Yanan, Perlin David S, Kreiswirth Barry N, Nguyen M Hong
Abstract excerpt
Doripenem-colistin exerts synergy against some, but not all, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains in vitro. We determined if doripenem MICs and/or ompK36 porin gene mutations impacted the responses of 23 sequence type 258 (ST258), KPC-2-producing strains to th...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.