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Article

Antibiotics and phages drive region-specific diversity of OmpK36 in Klebsiella pneumoniae.

mBio - 10 Sept 2025

Royer Guilhem, Laurenceau Raphaël, Cabanel Nicolas, Bardiaux Benjamin, Cerdas-Mejías Karol Melissa, Bikard David, Rosinski-Chupin Isabelle, Glaser Philippe

Abstract excerpt

The Enterobacterales outer membrane is impermeable to many antibiotics, but they can enter the cell via channel proteins, called porins. In Klebsiella pneumoniae, the porin OmpK36 is a major determinant of antibiotic resistance. Insertion of amino acids into the L3 constriction loop is frequently reported, leading to decreased channel size and reduced antibiotic susceptibility. While the involvement of the L3...

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Identifiers

PMID: 40823844
DOI: 10.1128/mbio.01343-25
PMCID: PMC12421954

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